Ontology highlight
ABSTRACT:
SUBMITTER: Lakovic K
PROVIDER: S-EPMC4269762 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Lakovic Katarina K Ai Jinglu J D'Abbondanza Josephine J Tariq Asma A Sabri Mohammed M Alarfaj Abdullah K AK Vasdev Punarjot P Macdonald Robert Loch RL
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20140827 11
Brain injury after intracerebral hemorrhage (ICH) occurs in cortex and white matter and may be mediated by blood breakdown products, including hemoglobin and heme. Effects of blood breakdown products, bilirubin and bilirubin oxidation products, have not been widely investigated in adult brain. Here, we first determined the effect of bilirubin and its oxidation products on the structure and function of white matter in vitro using brain slices. Subsequently, we determined whether these compounds h ...[more]