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ABSTRACT:
SUBMITTER: Reuss AJ
PROVIDER: S-EPMC4269781 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Biophysical journal 20141201 12
Synthetic riboswitches are versatile tools for the study and manipulation of biological systems. Yet, the underlying mechanisms governing its structural properties and regulation under physiological conditions are poorly studied. We performed spectroscopic and calorimetric experiments to explore the folding kinetics and thermodynamics of the tetracycline-binding aptamer, which can be employed as synthetic riboswitch, in the range of physiological magnesium concentrations. The dissociation consta ...[more]