Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia.
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ABSTRACT:
SUBMITTER: Jain RK
PROVIDER: S-EPMC4269830 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Publications
Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia.
Cancer cell 20141110 5
Ten antiangiogenic drugs targeting VEGF or its receptors are approved for cancer treatment. However, these agents, intended to block tumors' blood supply, may cause hypoxia, which may fuel tumor progression and treatment resistance. Emerging clinical data suggest that patients whose tumor perfusion or oxygenation increases in response to these agents may actually survive longer. Hence, strategies aimed at alleviating tumor hypoxia while improving perfusion may enhance the outcome of radiotherapy ...[more]
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