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ABSTRACT:
SUBMITTER: Williford JM
PROVIDER: S-EPMC4269835 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Williford John-Michael JM Ren Yong Y Huang Kevin K Pan Deng D Mao Hai-Quan HQ
Journal of materials chemistry. B 20141201 46
PEGylated polycation/DNA micellar nanoparticles have been developed that can undergo shape transformation upon cleavage of the PEG grafts in response to an environmental cue. As a proof-of-principle, DNA nanoparticles with higher PEG grafting density adopting long, worm- and rod-like morphologies, transition to more condensed nanoparticles with spherical and short-rod morphologies upon cleavage of a fraction of the PEG grafts from the copolymer. This shape transformation leads to increased surfa ...[more]