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Shape Transformation Following Reduction-Sensitive PEG Cleavage of Polymer/DNA Nanoparticles.


ABSTRACT: PEGylated polycation/DNA micellar nanoparticles have been developed that can undergo shape transformation upon cleavage of the PEG grafts in response to an environmental cue. As a proof-of-principle, DNA nanoparticles with higher PEG grafting density adopting long, worm- and rod-like morphologies, transition to more condensed nanoparticles with spherical and short-rod morphologies upon cleavage of a fraction of the PEG grafts from the copolymer. This shape transformation leads to increased surface charges, correlating with improved transfection efficiency.

SUBMITTER: Williford JM 

PROVIDER: S-EPMC4269835 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Shape Transformation Following Reduction-Sensitive PEG Cleavage of Polymer/DNA Nanoparticles.

Williford John-Michael JM   Ren Yong Y   Huang Kevin K   Pan Deng D   Mao Hai-Quan HQ  

Journal of materials chemistry. B 20141201 46


PEGylated polycation/DNA micellar nanoparticles have been developed that can undergo shape transformation upon cleavage of the PEG grafts in response to an environmental cue. As a proof-of-principle, DNA nanoparticles with higher PEG grafting density adopting long, worm- and rod-like morphologies, transition to more condensed nanoparticles with spherical and short-rod morphologies upon cleavage of a fraction of the PEG grafts from the copolymer. This shape transformation leads to increased surfa  ...[more]

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