The cofilin pathway in breast cancer invasion and metastasis.
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ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC4270061 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Publications
The cofilin pathway in breast cancer invasion and metastasis.
Wang Weigang W Eddy Robert R Condeelis John J
Nature reviews. Cancer 20070601 6
Recent evidence indicates that metastatic capacity is an inherent feature of breast tumours and not a rare, late acquired event. This has led to new models of metastasis. The interpretation of expression-profiling data in the context of these new models has identified the cofilin pathway as a major determinant of metastasis. Recent studies indicate that the overall activity of the cofilin pathway, and not that of any single gene within the pathway, determines the invasive and metastatic phenotyp ...[more]
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