Dataset Information

Serum IgG antibody levels to periodontal microbiota are associated with incident Alzheimer disease.

ABSTRACT:

Background

Periodontitis and Alzheimer disease (AD) are associated with systemic inflammation. This research studied serum IgG to periodontal microbiota as possible predictors of incident AD.

Methods

Using a case-cohort study design, 219 subjects (110 incident AD cases and 109 controls without incident cognitive impairment at last follow-up), matched on race-ethnicity, were drawn from the Washington Heights-Inwood Columbia Aging Project (WHICAP), a cohort of longitudinally followed northern Manhattan residents aged >65 years. Mean follow-up was five years (SD 2.6). In baseline sera, serum IgG levels were determined for bacteria known to be positively or negatively associated with periodontitis (Porphyromonas gingivalis, Tannerella forsythia, Actinobacillus actinomycetemcomitans Y4, Treponema denticola, Campylobacter rectus, Eubacterium nodatum, and Actinomyces naeslundii genospecies-2). In all analyses, we used antibody threshold levels shown to correlate with presence of moderate-severe periodontitis.

Results

Mean age was 72 years (SD 6.9) for controls, and 79 years (SD 4.6) for cases (p<0.001). Non-Hispanic Whites comprised 26%, non-Hispanic Blacks 27%, and Hispanics 48% of the sample. In a model adjusting for baseline age, sex, education, diabetes mellitus, hypertension, smoking, prior history of stroke, and apolipoprotein E genotype, high anti-A. naeslundii titer (>640 ng/ml, present in 10% of subjects) was associated with increased risk of AD (HR?=?2.0, 95%CI: 1.1-3.8). This association was stronger after adjusting for other significant titers (HR?=?3.1, 95%CI: 1.5-6.4). In this model, high anti-E. nodatum IgG (>1755 ng/ml; 19% of subjects) was associated with lower risk of AD (HR?=?0.5, 95%CI: 0.2-0.9).

Conclusions

Serum IgG levels to common periodontal microbiota are associated with risk for developing incident AD.

SUBMITTER: Noble JM

PROVIDER: S-EPMC4270775 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Publications

Serum IgG antibody levels to periodontal microbiota are associated with incident Alzheimer disease.

Noble James M JM Scarmeas Nikolaos N Celenti Romanita S RS Elkind Mitchell S V MS Wright Clinton B CB Schupf Nicole N Papapanou Panos N PN

PloS one 20141218 12

<h4>Background</h4>Periodontitis and Alzheimer disease (AD) are associated with systemic inflammation. This research studied serum IgG to periodontal microbiota as possible predictors of incident AD.<h4>Methods</h4>Using a case-cohort study design, 219 subjects (110 incident AD cases and 109 controls without incident cognitive impairment at last follow-up), matched on race-ethnicity, were drawn from the Washington Heights-Inwood Columbia Aging Project (WHICAP), a cohort of longitudinally followe ...[more]

PMID: 25522313

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Dataset Information

Serum IgG antibody levels to periodontal microbiota are associated with incident Alzheimer disease.

Background

Methods

Results

Conclusions

Publications

Serum IgG antibody levels to periodontal microbiota are associated with incident Alzheimer disease.

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