Ontology highlight
ABSTRACT:
SUBMITTER: Herias V
PROVIDER: S-EPMC4270842 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Herías Veronica V Biessen Erik A L EA Beckers Cora C Delsing Dianne D Liao Mengyang M Daemen Mat J MJ Pham Christine C T N CC Heeneman Sylvia S
Arteriosclerosis, thrombosis, and vascular biology 20141113 1
<h4>Objective</h4>The protein degrading activity of cathepsin C (CatC), combined with its role in leukocyte granule activation, suggests a contribution of this cystein protease in atherosclerosis. However, no experimental data are available to validate this concept.<h4>Approach and results</h4>CatC gene and protein expression were increased in ruptured versus advanced stable human carotid artery lesions. To assess causal involvement of CatC in plaque progression and stability, we generated LDLr( ...[more]