Serum-based miRNAs in the prediction and detection of recurrence in melanoma patients.

ABSTRACT:

Background

Identification of primary melanoma patients at the highest risk of recurrence remains a critical challenge, and monitoring for recurrent disease is limited to costly imaging studies. We recently reported our array-based discovery of prognostic serum miRNAs in melanoma. In the current study, we examined the clinical utility of these serum-based miRNAs for prognosis as well as detection of melanoma recurrence.

Methods

Serum levels of 12 miRNAs were tested using qRT-PCR at diagnosis in 283 melanoma patients (training cohort, n = 201; independent validation, n = 82; median follow-up, 68.8 months). A refined miRNA signature was chosen and evaluated. We also tested the potential clinical utility of the miRNAs in early detection and monitoring of recurrence using multipl

SUBMITTER: Fleming NH 

PROVIDER: S-EPMC4270907 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature