Ontology highlight
ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC4271057 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Wang Charlene C Abdel-Mohsen Mohamed M Strain Matthew C MC Lada Steven M SM Yukl Steven S Cockerham Leslie R LR Pilcher Christopher D CD Hecht Frederick M FM Sinclair Elizabeth E Liegler Teri T Richman Douglas D DD Deeks Steven G SG Pillai Satish K SK
The Journal of infectious diseases 20140616 11
Individuals who are heterozygous for the CCR5-Δ32 mutation provide a natural model to examine the effects of reduced CCR5 expression on human immunodeficiency virus (HIV) persistence. We evaluated the HIV reservoir in 18 CCR5-Δ32 heterozygotes and 54 CCR5 wild-type individuals during suppressive antiretroviral therapy. Cell-associated HIV RNA levels (P=.035), RNA to DNA transcriptional ratios (P=.013), and frequency of detectable HIV 2-long terminal repeat circular DNA (P=.013) were significantl ...[more]