Ontology highlight
ABSTRACT:
SUBMITTER: Herter-Sprie GS
PROVIDER: S-EPMC4271540 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Herter-Sprie Grit S GS Korideck Houari H Christensen Camilla L CL Herter Jan M JM Rhee Kevin K Berbeco Ross I RI Bennett David G DG Akbay Esra A EA Kozono David D Mak Raymond H RH Mike Makrigiorgos G G Kimmelman Alec C AC Wong Kwok-Kin KK
Nature communications 20141218
Close resemblance of murine and human trials is essential to achieve the best predictive value of animal-based translational cancer research. Kras-driven genetically engineered mouse models of non-small-cell lung cancer faithfully predict the response of human lung cancers to systemic chemotherapy. Owing to development of multifocal disease, however, these models have not been usable in studies of outcomes following focal radiotherapy (RT). We report the development of a preclinical platform to ...[more]