Ontology highlight
ABSTRACT:
SUBMITTER: Fu Y
PROVIDER: S-EPMC4271543 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Fu Yuan Y Lin Hongyu H Wisitpitthaya Somsinee S Blessing William A WA Aye Yimon Y
Chembiochem : a European journal of chemical biology 20140924 17
Human ribonucleotide reductase (hRNR) is a target of nucleotide chemotherapeutics in clinical use. The nucleotide-induced oligomeric regulation of hRNR subunit α is increasingly being recognized as an innate and drug-relevant mechanism for enzyme activity modulation. In the presence of negative feedback inhibitor dATP and leukemia drug clofarabine nucleotides, hRNR-α assembles into catalytically inert hexameric complexes, whereas nucleotide effectors that govern substrate specificity typically t ...[more]