Ontology highlight
ABSTRACT:
SUBMITTER: Itoe MA
PROVIDER: S-EPMC4271766 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Itoe Maurice A MA Sampaio Júlio L JL Cabal Ghislain G GG Real Eliana E Zuzarte-Luis Vanessa V March Sandra S Bhatia Sangeeta N SN Frischknecht Friedrich F Thiele Christoph C Shevchenko Andrej A Mota Maria M MM
Cell host & microbe 20141201 6
During invasion, Plasmodium, the causative agent of malaria, wraps itself in a parasitophorous vacuole membrane (PVM), which constitutes a critical interface between the parasite and its host cell. Within hepatocytes, each Plasmodium sporozoite generates thousands of new parasites, creating high demand for lipids to support this replication and enlarge the PVM. Here, a global analysis of the total lipid repertoire of Plasmodium-infected hepatocytes reveals an enrichment of neutral lipids and the ...[more]