An improved model for the hTERT promoter quadruplex.
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ABSTRACT:
SUBMITTER: Chaires JB
PROVIDER: S-EPMC4272262 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
An improved model for the hTERT promoter quadruplex.
Chaires Jonathan B JB Trent John O JO Gray Robert D RD Dean William L WL Buscaglia Robert R Thomas Shelia D SD Miller Donald M DM
PloS one 20141219 12
Mutations occur at four specific sites in the hTERT promoter in >75% of glioblastomas and melanomas, but the mechanism by which the mutations affect gene expression remains unexplained. We report biophysical computational studies that show that the hTERT promoter sequence forms a novel G-quadruplex structure consisting of three contiguous, stacked parallel quadruplexes. The reported hTERT mutations map to the central quadruplex within this structure, and lead to an alteration of its hydrodynamic ...[more]
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