Ontology highlight
ABSTRACT:
SUBMITTER: Kumar A
PROVIDER: S-EPMC4272528 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Kumar Akash A Boyle Evan A EA Tokita Mari M Mikheev Andrei M AM Sanger Michelle C MC Girard Emily E Silber John R JR Gonzalez-Cuyar Luis F LF Hiatt Joseph B JB Adey Andrew A Lee Choli C Kitzman Jacob O JO Born Donald E DE Silbergeld Daniel L DL Olson James M JM Rostomily Robert C RC Shendure Jay J
Genome biology 20141203 12
<h4>Background</h4>The extent of intratumoral mutational heterogeneity remains unclear in gliomas, the most common primary brain tumors, especially with respect to point mutation. To address this, we applied single molecule molecular inversion probes targeting 33 cancer genes to assay both point mutations and gene amplifications within spatially distinct regions of 14 glial tumors.<h4>Results</h4>We find evidence of regional mutational heterogeneity in multiple tumors, including mutations in TP5 ...[more]