Ontology highlight
ABSTRACT:
SUBMITTER: Fan CW
PROVIDER: S-EPMC4272670 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Chemistry & biology 20141204 12
Misactivation of the seven-transmembrane protein Smoothened (Smo) is frequently associated with basal cell carcinoma and medulloblastoma. Cellular exposure to secreted Hedgehog (Hh) protein or oncogenic mutations in Hh pathway components induces Smo accumulation in the primary cilium, an antenna-like organelle with mostly unknown cellular functions. Despite the data supporting an indispensable role of the primary cilium in Smo activation, the mechanistic underpinnings of this dependency remain u ...[more]