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Galactan synthesis in a single step via oligomerization of monosaccharides.

ABSTRACT: Galactans ranging in length from one to five residues were prepared in a single step by treatment of the glycosyl donor 2,3,4-tri-O-benzoyl-?-D-galactopyranosyl fluoride with lanthanum perchlorate in the presence of an initiator alcohol. The product oligosaccharides were readily chromatographically separable. This oligomerization was used to synthesize a pentagalactan in a single step from monosaccharide building blocks in reasonable overall yields.

SUBMITTER: Drager M

PROVIDER: S-EPMC4273286 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Galactan synthesis in a single step via oligomerization of monosaccharides.

Dräger Marius M Basu Amit A

Beilstein journal of organic chemistry 20141113

Galactans ranging in length from one to five residues were prepared in a single step by treatment of the glycosyl donor 2,3,4-tri-O-benzoyl-β-D-galactopyranosyl fluoride with lanthanum perchlorate in the presence of an initiator alcohol. The product oligosaccharides were readily chromatographically separable. This oligomerization was used to synthesize a pentagalactan in a single step from monosaccharide building blocks in reasonable overall yields. ...[more]

PMID: 25550728

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