Ontology highlight
ABSTRACT:
SUBMITTER: Dielmann-Gessner J
PROVIDER: S-EPMC4273380 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Dielmann-Gessner Jessica J Grossman Moran M Conti Nibali Valeria V Born Benjamin B Solomonov Inna I Fields Gregg B GB Havenith Martina M Sagi Irit I
Proceedings of the National Academy of Sciences of the United States of America 20141125 50
The main focus of enzymology is on the enzyme rates, substrate structures, and reactivity, whereas the role of solvent dynamics in mediating the biological reaction is often left aside owing to its complex molecular behavior. We used integrated X-ray- and terahertz- based time-resolved spectroscopic tools to study protein-water dynamics during proteolysis of collagen-like substrates by a matrix metalloproteinase. We show equilibration of structural kinetic transitions in the millisecond timescal ...[more]