Ontology highlight
ABSTRACT:
SUBMITTER: Brown CR
PROVIDER: S-EPMC4273403 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Brown Christopher R CR Boeger Hinrich H
Proceedings of the National Academy of Sciences of the United States of America 20141202 50
Gene product molecule numbers fluctuate over time and between cells, confounding deterministic expectations. The molecular origins of this noise of gene expression remain unknown. Recent EM analysis of single PHO5 gene molecules of yeast indicated that promoter molecules stochastically assume alternative nucleosome configurations at steady state, including the fully nucleosomal and nucleosome-free configuration. Given that distinct configurations are unequally conducive to transcription, the nuc ...[more]