Ontology highlight
ABSTRACT:
SUBMITTER: Mihailescu M
PROVIDER: S-EPMC4273406 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Mihailescu Mihaela M Krepkiy Dmitriy D Milescu Mirela M Gawrisch Klaus K Swartz Kenton J KJ White Stephen S
Proceedings of the National Academy of Sciences of the United States of America 20141201 50
Protein toxins from tarantula venom alter the activity of diverse ion channel proteins, including voltage, stretch, and ligand-activated cation channels. Although tarantula toxins have been shown to partition into membranes, and the membrane is thought to play an important role in their activity, the structural interactions between these toxins and lipid membranes are poorly understood. Here, we use solid-state NMR and neutron diffraction to investigate the interactions between a voltage sensor ...[more]