Ontology highlight
ABSTRACT:
SUBMITTER: Cavalieri V
PROVIDER: S-EPMC4273433 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Cavalieri Vincenzo V Spinelli Giovanni G
eLife 20141202
Dorsal/ventral (DV) patterning of the sea urchin embryo relies on a ventrally-localized organizer expressing Nodal, a pivotal regulator of the DV gene regulatory network. However, the inceptive mechanisms imposing the symmetry-breaking are incompletely understood. In Paracentrotus lividus, the Hbox12 homeodomain-containing repressor is expressed by prospective dorsal cells, spatially facing and preceding the onset of nodal transcription. We report that Hbox12 misexpression provokes DV abnormalit ...[more]