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Combination of two candidate subunit vaccine antigens elicits protective immunity to ricin and anthrax toxin in mice.

ABSTRACT: In an effort to develop combination vaccines for biodefense, we evaluated a ricin subunit antigen, RiVax, given in conjunction with an anthrax protective antigen, DNI. The combination led to high endpoint titer antibody response, neutralizing antibodies, and protective immunity against ricin and anthrax lethal toxin. This is a natural combination vaccine, since both antigens are recombinant subunit proteins that would be given to the same target population.

SUBMITTER: Vance DJ

PROVIDER: S-EPMC4274239 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Combination of two candidate subunit vaccine antigens elicits protective immunity to ricin and anthrax toxin in mice.

Vance David J DJ Rong Yinghui Y Brey Robert N RN Mantis Nicholas J NJ

Vaccine 20141202 3

In an effort to develop combination vaccines for biodefense, we evaluated a ricin subunit antigen, RiVax, given in conjunction with an anthrax protective antigen, DNI. The combination led to high endpoint titer antibody response, neutralizing antibodies, and protective immunity against ricin and anthrax lethal toxin. This is a natural combination vaccine, since both antigens are recombinant subunit proteins that would be given to the same target population. ...[more]

PMID: 25475957

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