Ontology highlight
ABSTRACT:
SUBMITTER: Garg R
PROVIDER: S-EPMC4274801 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Garg Rajesh R Rao Ajay D AD Baimas-George Maria M Hurwitz Shelley S Foster Courtney C Shah Ravi V RV Jerosch-Herold Michael M Kwong Raymond Y RY Di Carli Marcelo F MF Adler Gail K GK
Diabetes 20140814 1
Reduced coronary flow reserve (CFR), an indicator of coronary microvascular dysfunction, is seen in type 2 diabetes mellitus (T2DM) and predicts cardiac mortality. Since aldosterone plays a key role in vascular injury, the aim of this study was to determine whether mineralocorticoid receptor (MR) blockade improves CFR in individuals with T2DM. Sixty-four men and women with well-controlled diabetes on chronic ACE inhibition (enalapril 20 mg/day) were randomized to add-on therapy of spironolactone ...[more]