Ontology highlight
ABSTRACT:
SUBMITTER: Marleau AM
PROVIDER: S-EPMC4275030 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Marleau Annette M AM Sarvetnick Nora E NE
Journal of autoimmunity 20110316 3-4
IL-18 has a well-established role in pro-inflammatory responses in the islets in type 1 diabetes. Here, we identify a distinctive role for IL-18 in expanding pathogenic T cells in the periphery of NOD mice. Well in advance of disease onset, the periphery of IL-18-deficient mice exhibits reduced T cell turnover, an increased prevalence of naïve and quiescent T cells, emergence of fewer effector T cells, and disease protection. Islet-reactive T cells fail to become activated in the lymphoid organs ...[more]