Ontology highlight
ABSTRACT:
SUBMITTER: Kudva A
PROVIDER: S-EPMC4275066 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Kudva Anupa A Scheller Erich V EV Robinson Keven M KM Crowe Chris R CR Choi Sun Mi SM Slight Samantha R SR Khader Shabaana A SA Dubin Patricia J PJ Enelow Richard I RI Kolls Jay K JK Alcorn John F JF
Journal of immunology (Baltimore, Md. : 1950) 20101222 3
Staphylococcus aureus is a significant cause of hospital and community acquired pneumonia and causes secondary infection after influenza A. Recently, patients with hyper-IgE syndrome, who often present with S. aureus infections of the lung and skin, were found to have mutations in STAT3, required for Th17 immunity, suggesting a potential critical role for Th17 cells in S. aureus pneumonia. Indeed, IL-17R(-/-) and IL-22(-/-) mice displayed impaired bacterial clearance of S. aureus compared with t ...[more]