Ontology highlight
ABSTRACT:
SUBMITTER: Sirianni RW
PROVIDER: S-EPMC4275164 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Sirianni Rachael W RW Zheng Ming-Qiang MQ Patel Toral R TR Shafbauer Thomas T Zhou Jiangbing J Saltzman W Mark WM Carson Richard E RE Huang Yiyun Y
Bioconjugate chemistry 20141201 12
The avidin-biotin interaction permits rapid and nearly irreversible noncovalent linkage between biotinylated molecules and avidin-modified substrates. We designed a biotinylated radioligand intended for use in the detection of avidin-modified polymer nanoparticles in tissue with positron emission tomography (PET). Using an F-18 labeled prosthetic group, [(18)F]4-fluorobenzylamine, and a commercially available biotin derivate, NHS-PEG4-biotin, [(18)F]-fluorobenzylamide-poly(ethylene glycol)4-biot ...[more]