Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez-Granado JM
PROVIDER: S-EPMC4275242 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
González-Granado Jose M JM Navarro-Puche Ana A Molina-Sanchez Pedro P Blanco-Berrocal Marta M Viana Rosa R Font de Mora Jaime J Andrés Vicente V
PloS one 20141223 12
Nuclear lamins are important structural and functional proteins in mammalian cells, but little is known about the mechanisms and cofactors that regulate their traffic into the nucleus. Here, we demonstrate that trafficking of lamin A, but not lamin B1, and its assembly into the nuclear envelope are regulated by sorting nexin 6 (SNX6), a major component of the retromer that targets proteins and other molecules to specific subcellular locations. SNX6 interacts with lamin A in vitro and in vivo and ...[more]