Ontology highlight
ABSTRACT:
SUBMITTER: Huemer M
PROVIDER: S-EPMC4276288 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Huemer Michael M Rebhandl Stefan S Zaborsky Nadja N Gassner Franz J FJ Hainzl Stefan S Weiss Lukas L Hebenstreit Daniel D Greil Richard R Geisberger Roland R
European journal of immunology 20141018 12
The activation-induced cytidine deaminase (AID) mediates somatic hypermutation and class switch recombination of the Ig genes by directly deaminating cytosines to uracils. As AID causes a substantial amount of off-target mutations, its activity has been associated with lymphomagenesis and clonal evolution of B-cell malignancies. Although it has been shown that AID is expressed in B-cell chronic lymphocytic leukemia (CLL), a clear analysis of in vivo AID activity in this B-cell malignancy remaine ...[more]