Populations of metal-glycan structures influence MS fragmentation patterns.
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ABSTRACT:
SUBMITTER: Zhu F
PROVIDER: S-EPMC4276451 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Publications
Populations of metal-glycan structures influence MS fragmentation patterns.
Zhu Feifei F Glover Matthew S MS Shi Huilin H Trinidad Jonathan C JC Clemmer David E DE
Journal of the American Society for Mass Spectrometry 20141015 1
The structures and collision-induced dissociation (CID) fragmentation patterns of the permethylated glycan Man5GlcNAc2 are investigated by a combination of hybrid ion mobility spectrometry (IMS), mass spectrometry (MS), and MS/MS techniques. IMS analysis of eight metal-adducted glycans ([Man5GlcNAc2 + M](2+), where M = Mn, Fe, Co, Ni, Cu, Mg, Ca, and Ba) shows distinct conformer patterns. These conformers appear to arise from individual metals binding at different sites on the glycan. Fragmentat ...[more]
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