Ontology highlight
ABSTRACT:
SUBMITTER: Ribeiro AJ
PROVIDER: S-EPMC4276563 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Ribeiro Alexandre J S AJ Khanna Payal P Sukumar Aishwarya A Dong Cheng C Dahl Kris Noel KN
Cellular and molecular bioengineering 20141201 4
During metastasis, melanoma cells must be sufficiently deformable to squeeze through extracellular barriers with small pore sizes. We visualize and quantify deformability of single cells using micropipette aspiration and examine the migration potential of a population of melanoma cells using a flow migration apparatus. We artificially stiffen the nucleus with recombinant overexpression of Δ50 lamin A, which is found in patients with Hutchison Gilford progeria syndrome and in aged individuals. Me ...[more]