Ontology highlight
ABSTRACT:
SUBMITTER: Oh S
PROVIDER: S-EPMC4276742 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Oh Seunghoon S Bargiello Thaddeus A TA
Yonsei medical journal 20150101 1
Voltage is an important parameter that regulates the conductance of both intercellular and plasma membrane channels (undocked hemichannels) formed by the 21 members of the mammalian connexin gene family. Connexin channels display two forms of voltage-dependence, rectification of ionic currents and voltage-dependent gating. Ionic rectification results either from asymmetries in the distribution of fixed charges due to heterotypic pairing of different hemichannels, or by channel block, arising fro ...[more]