A polymorphism of the renin gene rs6682082 is associated with essential hypertension risk and blood pressure levels in Korean women.

ABSTRACT:

Purpose

The aim of the present study was to investigate associations between the renin gene (REN) and the risk of essential hypertension and blood pressure (BP) levels in Koreans.

Materials and methods

To outline the functional role of a single nucleotide polymorphism in the transcription of the REN gene, we conducted a case-control study of 1975 individuals: 646 hypertension (HT) patients and 1329 ethnically and age-matched normotensive subjects.

Results

Logistic regression analysis indicated that the genotypes AA/AG were strongly associated with risk of HT (odds ratio, 1.493; 95% confidence interval, 1.069-2.086, p=0.018) in female subjects. The genotypes AA/AG also showed significant association with higher blood pressure levels, both systolic and diastolic, in pos

SUBMITTER: Park J 

PROVIDER: S-EPMC4276760 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature