Ontology highlight
ABSTRACT:
SUBMITTER: Dietrich A
PROVIDER: S-EPMC4276908 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Dietrich Alexander A Fahlbusch Meike M Gudermann Thomas T
Cells 20140929 4
In contrast to other Classical Transient Receptor Potential TRPC channels the function of TRPC1 as an ion channel is a matter of debate, because it is often difficult to obtain substantial functional signals over background in response to over-expression of TRPC1 alone. Along these lines, heterologously expressed TRPC1 is poorly translocated to the plasma membrane as a homotetramer and may not function on its own physiologically, but may rather be an important linker and regulator protein in het ...[more]