Ontology highlight
ABSTRACT:
SUBMITTER: Morais-Cabral JH
PROVIDER: S-EPMC4277939 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Morais-Cabral João H JH Robertson Gail A GA
Journal of molecular biology 20140823 1
KCNH channels are expressed across a vast phylogenetic and evolutionary spectrum. In humans, they function in a wide range of tissues and serve as biomarkers and targets for diseases such as cancer and cardiac arrhythmias. These channels share a general architecture with other voltage-gated ion channels but are distinguished by the presence of an N-terminal PAS (Per-Arnt-Sim) domain and a C-terminal domain with homology to cyclic nucleotide binding domains (referred to as the CNBh domain). Cytos ...[more]