Ontology highlight
ABSTRACT:
SUBMITTER: Bagneris C
PROVIDER: S-EPMC4278185 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Bagnéris Claire C Naylor Claire E CE McCusker Emily C EC Wallace B A BA
The Journal of general physiology 20141215 1
In excitable cells, the initiation of the action potential results from the opening of voltage-gated sodium channels. These channels undergo a series of conformational changes between open, closed, and inactivated states. Many models have been proposed for the structural transitions that result in these different functional states. Here, we compare the crystal structures of prokaryotic sodium channels captured in the different conformational forms and use them as the basis for examining molecula ...[more]