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Three new asperentin derivatives from the algicolous fungus Aspergillus sp. F00785.

ABSTRACT: Three new asperentin-type compounds, 6-O-?-d-ribosylasperentin (1) and 6-O-?-d-ribosyl-8-O-methylasperentin (2) and 5-hydroxyl-6-O-methylasperentin (3), along with asperentin (4) and its known analogues (5-9), were isolated from a halotolerant Aspergillus sp. strain F00785, an endotrophic fungus from marine alga. Their structures were determined using extensive NMR and HRESIMS spectroscopic analysis, including the X-ray crystallographic data for the assignment of the absolute configurations of compound 9. Compound 4 exhibited highly potent inhibitory activity against crop pathogens, Colletotrichum gleosporioides Penz. and Colletotrichum gleosporioides (Penz.) Sacc.

SUBMITTER: Tang Q

PROVIDER: S-EPMC4278214 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Three new asperentin derivatives from the algicolous fungus Aspergillus sp. F00785.

Tang Qian Q Guo Kai K Li Xiao-Yang XY Zheng Xiu-Ying XY Kong Xiang-Jian XJ Zheng Zhong-Hui ZH Xu Qing-Yan QY Deng Xianming X

Marine drugs 20141215 12

Three new asperentin-type compounds, 6-O-α-d-ribosylasperentin (1) and 6-O-α-d-ribosyl-8-O-methylasperentin (2) and 5-hydroxyl-6-O-methylasperentin (3), along with asperentin (4) and its known analogues (5-9), were isolated from a halotolerant Aspergillus sp. strain F00785, an endotrophic fungus from marine alga. Their structures were determined using extensive NMR and HRESIMS spectroscopic analysis, including the X-ray crystallographic data for the assignment of the absolute configurations of c ...[more]

PMID: 25517217

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