Ontology highlight
ABSTRACT:
SUBMITTER: Hampson P
PROVIDER: S-EPMC4278328 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Hampson Peter P Wang Keqing K Ersvær Elisabeth E McCormack Emmet E Schüler Julia J Fiebig Heinz-Herbert HH Gjertsen Bjørn Tore BT Bruserud Øystein Ø Lord Janet M JM
Oncoscience 20140806 8
We showed previously that PEP005 induced apoptosis in leukaemic cell lines and blasts from patients with acute myeloid leukaemia (AML). Here we assess the anti-leukeamic effects of PEP005 in vivo and determine the mechanism of resistance of PEP005 non-responsive cells. We used 2 human xenograft mouse models of AML to assess the anti-leukaemic effects of PEP005 in vivo. Expression microarray analysis of primary AML blasts following treatment with PEP005 was used to determine patterns of gene expr ...[more]