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Phytochemical, Antimicrobial and Antiplasmodial Investigations of Terminalia brownii.


ABSTRACT: Phytochemical investigation of the ethyl acetate-soluble fraction of stem bark extract of an African medicinal plant Terminalia brownii led to the isolation of a new oleanane-type triterpenoid, along with seven known triterpenoids, seven ellagic acid derivatives, and 3-O-?-D-glucopyranosyl-?-sitosterol. The new compound was identified using spectroscopic methods, notably 1D- and 2D NMR, as 3?,24-O-ethylidenyl-2?,19?-dihydroxyolean-12-en-28-oic acid. The isolated compounds were evaluated for their antimicrobial and antiplasmodial activities. Two compounds with a galloyl group (4 and 6) were found to be active against chloroquine sensitive (D6) and chloroquine resistant (W2) strains of Plasmodium falciparum, whereas three ellagic acid derivatives (5-7) were found active against three species of fungi and one species of bacteria.

SUBMITTER: Machumi F 

PROVIDER: S-EPMC4278643 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature

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Phytochemical, Antimicrobial and Antiplasmodial Investigations of <i>Terminalia brownii.</i>

Machumi Francis F   Midiwo Jacob O JO   Jacob Melissa R MR   Khan Shabana I SI   Tekwani Babu L BL   Zhang Jin J   Walker Larry A LA   Muhammad Ilias I  

Natural product communications 20130701 6


Phytochemical investigation of the ethyl acetate-soluble fraction of stem bark extract of an African medicinal plant <i>Terminalia brownii</i> led to the isolation of a new oleanane-type triterpenoid, along with seven known triterpenoids, seven ellagic acid derivatives, and 3-<i>O</i>-β-D-glucopyranosyl-β-sitosterol. The new compound was identified using spectroscopic methods, notably 1D- and 2D NMR, as 3β,24-<i>O</i>-ethylidenyl-2α,19α-dihydroxyolean-12-en-28-oic acid. The isolated compounds we  ...[more]

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