Characterization of Chlamydia trachomatis omp1 genotypes detected in eye swab samples from remote Australian communities.

ABSTRACT: Chlamydia trachomatis conjunctival samples collected over a 6-month period from individuals with clinical signs of trachoma and located in remote communities in the Australian Northern Territory were differentially characterized according to serovar and variants. The rationale was to gain an understanding of the epidemiology of an apparent increased prevalence of acute trachoma in areas thought to be less conducive to this disease. Characterization was performed through sequencing of a region of the omp1 gene spanning the four variable domains and encoding the major outer membrane protein. Nucleotide and deduced amino acid sequences were genotyped by using a BLAST similarity search and were examined by phylogenetic analyses to illustrate evolutionary relationships between the clinical and

SUBMITTER: Stevens MP 

PROVIDER: S-EPMC427869 | biostudies-literature | 2004 Jun

REPOSITORIES: biostudies-literature