Ontology highlight
ABSTRACT:
SUBMITTER: Phillips-Krawczak CA
PROVIDER: S-EPMC4279232 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Phillips-Krawczak Christine A CA Singla Amika A Starokadomskyy Petro P Deng Zhihui Z Osborne Douglas G DG Li Haiying H Dick Christopher J CJ Gomez Timothy S TS Koenecke Megan M Zhang Jin-San JS Dai Haiming H Sifuentes-Dominguez Luis F LF Geng Linda N LN Kaufmann Scott H SH Hein Marco Y MY Wallis Mathew M McGaughran Julie J Gecz Jozef J Sluis Bart van de Bv Billadeau Daniel D DD Burstein Ezra E
Molecular biology of the cell 20141029 1
COMMD1 deficiency results in defective copper homeostasis, but the mechanism for this has remained elusive. Here we report that COMMD1 is directly linked to early endosomes through its interaction with a protein complex containing CCDC22, CCDC93, and C16orf62. This COMMD/CCDC22/CCDC93 (CCC) complex interacts with the multisubunit WASH complex, an evolutionarily conserved system, which is required for endosomal deposition of F-actin and cargo trafficking in conjunction with the retromer. Interact ...[more]