Ontology highlight
ABSTRACT:
SUBMITTER: Cainap C
PROVIDER: S-EPMC4279237 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Cainap Calin C Qin Shukui S Huang Wen-Tsung WT Chung Ik Joo IJ Pan Hongming H Cheng Ying Y Kudo Masatoshi M Kang Yoon-Koo YK Chen Pei-Jer PJ Toh Han-Chong HC Gorbunova Vera V Eskens Ferry A L M FA Qian Jiang J McKee Mark D MD Ricker Justin L JL Carlson Dawn M DM El-Nowiem Saied S
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20141208 2
<h4>Purpose</h4>This open-label phase III trial evaluated efficacy and tolerability of linifanib versus sorafenib in patients with advanced hepatocellular carcinoma (HCC) without prior systemic therapy.<h4>Patients and methods</h4>Patients were randomly assigned in a 1:1 ratio to linifanib 17.5 mg once daily or sorafenib 400 mg twice daily. Patients were stratified by region (Outside Asia, Japan, and rest of Asia), Eastern Cooperative Oncology Group performance score (ECOG PS; 0 or 1), vascular ...[more]