Ontology highlight
ABSTRACT:
SUBMITTER: Lau YK
PROVIDER: S-EPMC4279389 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Lau Ying-Ka Ingar YK Du Xing X Rayannavar Vinayak V Hopkins Benjamin B Shaw Jacquelyn J Bessler Eliana E Thomas Tiffany T Pires Maira M MM Keniry Megan M Parsons Ramon E RE Cremers Serge S Szabolcs Matthias M Maurer Matthew A MA
Oncotarget 20141101 21
Basal-like breast cancers (BBCs) are enriched for increased EGFR expression and decreased expression of PTEN. We found that treatment with metformin and erlotinib synergistically induced apoptosis in a subset of BBC cell lines. The drug combination led to enhanced reduction of EGFR, AKT, S6 and 4EBP1 phosphorylation, as well as prevented colony formation and inhibited mammosphere outgrowth. Our data with other compounds suggested that biguanides combined with EGFR inhibitors have the potential t ...[more]