Ontology highlight
ABSTRACT:
SUBMITTER: Starke C
PROVIDER: S-EPMC4279744 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Starke Charlotte C Betz Hannah H Hickmann Linda L Lachmann Peter P Neubauer Björn B Kopp Jeffrey B JB Sequeira-Lopez Maria Luisa S ML Gomez R Ariel RA Hohenstein Bernd B Todorov Vladimir T VT Hugo Christian P M CP
Journal of the American Society of Nephrology : JASN 20140605 1
Mesangial cell injury has a major role in many CKDs. Because renin-positive precursor cells give rise to mesangial cells during nephrogenesis, this study tested the hypothesis that the same phenomenon contributes to glomerular regeneration after murine experimental mesangial injury. Mesangiolysis was induced by administration of an anti-mesangial cell serum in combination with LPS. In enhanced green fluorescent protein-reporter mice with constitutively labeled renin lineage cells, the size of th ...[more]