Ontology highlight
ABSTRACT:
SUBMITTER: Fu Y
PROVIDER: S-EPMC4280578 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Fu Ying Y Zhang Ningnannan N Ren Li L Yan Yaping Y Sun Na N Li Yu-Jing YJ Han Wei W Xue Rong R Liu Qiang Q Hao Junwei J Yu Chunshui C Shi Fu-Dong FD
Proceedings of the National Academy of Sciences of the United States of America 20141208 51
Peripheral lymphocytes entering brain ischemic regions orchestrate inflammatory responses, catalyze tissue death, and worsen clinical outcomes of acute ischemic stroke (AIS) in preclinical studies. However, it is not known whether modulating brain inflammation can impact the outcome of patients with AIS. In this open-label, evaluator-blinded, parallel-group clinical pilot trial, we recruited 22 patients matched for clinical and MRI characteristics, with anterior cerebral circulation occlusion an ...[more]