Ontology highlight
ABSTRACT:
SUBMITTER: Stepaniants S
PROVIDER: S-EPMC4280711 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Stepaniants Sergey S Wang I-Ming IM Boie Yves Y Mortimer James J Kennedy Brian B Elliott Mark M Hayashi Shizu S Luo Honglin H Wong Jerry J Loy Leanna L Coulter Silvija S Roberts Christopher J CJ Hogg James C JC Sin Don D DD O'Neill Gary G Crackower Michael M Morris Melody M Paré Peter D PD Obeidat Ma'en M
BMC pulmonary medicine 20141129
<h4>Background</h4>Increased small airway resistance and decreased lung elasticity contribute to the airflow limitation in chronic obstructive pulmonary disease (COPD). The lesion that corresponds to loss of lung elasticity is emphysema; the small airway obstruction is due to inflammatory narrowing and obliteration. Despite their convergence in altered physiology, different mechanisms contribute to these processes. The relationships between gene expression and these specific phenotypes may be mo ...[more]