Limited perturbation of a DPPC bilayer by fluorescent lipid probes: a molecular dynamics study.
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ABSTRACT:
SUBMITTER: Ackerman DG
PROVIDER: S-EPMC4280801 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Publications
Limited perturbation of a DPPC bilayer by fluorescent lipid probes: a molecular dynamics study.
Ackerman David G DG Heberle Frederick A FA Feigenson Gerald W GW
The journal of physical chemistry. B 20130419 17
The properties of lipid bilayer nanometer-scale domains could be crucial for understanding cell membranes. Fluorescent probes are often used to study bilayers, yet their effects on host lipids are not well understood. We used molecular dynamics simulations to investigate perturbations in a fluid DPPC bilayer upon incorporation of three indocarbocyanine probes: DiI-C18:0, DiI-C18:2, or DiI-C12:0. We find a 10-12% decrease in chain order for DPPC in the solvation shell nearest the probe but smalle ...[more]
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