Ontology highlight
ABSTRACT:
SUBMITTER: Shi J
PROVIDER: S-EPMC4281042 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Shi Jian J Mao Ning-Fang NF Wang Li L Zhang Han-Bo HB Chen Qian Q Liu Hua H Tang Xun X Jin Tao T Zhu Chong-Tao CT Li Fu-Bing FB Sun Lin-Hui LH Xu Xin-Ming XM Xu Yong-Qing YQ
PloS one 20141231 12
Infection by methicillin-resistant Staphylococcus aureus (MRSA) is a life-threatening condition, and formation of biofilms can lead to treatment failure in a clinical setting. The aim of this study was to demonstrate the in vivo bactericidal effects of a combination of vancomycin (VAN) and fosfomycin (FOS) against MRSA in a rat carboxymethyl cellulose-pouch biofilm model. The results of the time-kill assay showed that the combination therapy was capable of killing at low minimal inhibitory conce ...[more]