Ontology highlight
ABSTRACT:
SUBMITTER: Huang J
PROVIDER: S-EPMC4281731 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Huang Jianyun J Sun Yutong Y Zhang J Jillian JJ Huang Xin-Yun XY
The Journal of biological chemistry 20141120 1
G protein-coupled receptors (GPCRs) relay extracellular signals mainly to heterotrimeric G-proteins (Gαβγ) and they are the most successful drug targets. The mechanisms of G-protein activation by GPCRs are not well understood. Previous studies have revealed a signal relay route from a GPCR via the C-terminal α5-helix of Gα to the guanine nucleotide-binding pocket. Recent structural and biophysical studies uncover a role for the opening or rotating of the α-helical domain of Gα during the activat ...[more]