Ontology highlight
ABSTRACT:
SUBMITTER: Ichikawa D
PROVIDER: S-EPMC4282382 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Ichikawa Daiju D Asano Masanao M Shinton Susan A SA Brill-Dashoff Joni J Formica Anthony M AM Velcich Anna A Hardy Richard R RR Hayakawa Kyoko K
Journal of immunology (Baltimore, Md. : 1950) 20141205 2
Expression of a germline VH3609/D/JH2 IgH in mice results in the generation of B1 B cells with anti-thymocyte/Thy-1 glycoprotein autoreactivity by coexpression of Vk21-5/Jk2 L chain leading to production of serum IgM natural autoantibody. In these same mice, the marginal zone (MZ) B cell subset in spleen shows biased usage of a set of Ig L chains different from B1 B cells, with 30% having an identical Vk19-17/Jk1 L chain rearrangement. This VH3609/Vk19-17 IgM is reactive with intestinal goblet c ...[more]