Ontology highlight
ABSTRACT:
SUBMITTER: Tzanis A
PROVIDER: S-EPMC4282423 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Tzanis Angelos A Dalton Kate A KA Hesketh Andrew A den Hengst Chris D CD Buttner Mark J MJ Thibessard Annabelle A Kelemen Gabriella H GH
Molecular microbiology 20131219 2
The RNA polymerase sigma factor SigF controls late development during sporulation in the filamentous bacterium Streptomyces coelicolor. The only known SigF-dependent gene identified so far, SCO5321, is found in the biosynthetic cluster encoding spore pigment synthesis. Here we identify the first direct target for SigF, the gene sspA, encoding a sporulation-specific protein. Bioinformatic analysis suggests that SspA is a secreted lipoprotein with two PepSY signature domains. The sspA deletion mut ...[more]