Ontology highlight
ABSTRACT:
SUBMITTER: Ziauddeen H
PROVIDER: S-EPMC4282435 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Ziauddeen Hisham H Nathan Pradeep J PJ Dodds Chris C Maltby Kay K Miller Sam R SR Waterworth Dawn D Song Kijoung K Warren Liling L Hosking Louise L Zucchetto Mauro M Bush Mark M Johnson Lakshmi Vasist LV Sarai Bhopinder B Mogg Karin K Bradley Brendan P BP Richards Duncan B DB Fletcher Paul C PC Bullmore Edward T ET
Journal of clinical pharmacology 20130811 10
The mu-opioid system has a key role in hedonic and motivational processes critical to substance addiction. However, existing mu-opioid antagonists have had limited success as anti-addiction treatments. GSK1521498 is a selective and potent mu-opioid antagonist being developed for the treatment of overeating and substance addictions. In this study, 28 healthy participants were administered single doses of GSK1521498 20 mg, ethanol 0.5 g/kg body weight, or both in combination, in a double blind pla ...[more]